Gene Therapy and Novel Revascularization Approaches 1998-2001
ESC 2001 Meeting Coverage
LATE BREAKING CLINICAL TRIALS - SLIDE SETS DIRECTLY FROM THE PRESENTERS
TCTMD Slide Sets
AHA 2001 Meeting Coverage
Muscle cell transplants to
infarcted heart tissue improve contractility
Reported By: Martha Kerr
Click
here to view
Chimerism of the Transplanted Heart
Federico Quaini, M.D || Piero Anversa, M.D.
N Engl J Med 2002;346:5-15
http://content.nejm.org/cgi/content/short/346/1/5
Eight male patients received cardiac transplants from female donors. In samples
from these hearts, the investigators were able to detect Y chromosomes in about
10 percent of the myocytes, proving that they came from the male recipients.
These results show that cells from the recipient are able to migrate into the
donor heart and take up residence. Some of the Y-chromosome–positive cells
were primitive and had the capacity to proliferate.
The origin of the cells that migrated from the recipient to the transplanted
heart is uncertain, but this study raises the possibility that primitive cells
from the recipient may migrate to the donor heart and participate in the
remodeling process.
Related Perspective
Can the Heart Repair Itself?
R.S. Schwartz and G.D. Curfman
N Engl J Med 2002;346:2-4
http://content.nejm.org/cgi/content/short/346/1/2?query=TOC
Related Editorial
Regeneration of the Human Heart -- No Chimera?
R. Bolli
N Engl J Med 2002;346:55-56
http://content.nejm.org/cgi/content/short/346/1/55?query=TOC
More evidence suggests the heart can
regenerate itself
http://www.theheart.org/index.cfm?doc_id=27645
http://cardiology.medscape.com/46705.rhtml?srcmp=card-010402
Investigators examining female hearts that were transplanted into male
recipients have discovered that cardiac cells from the male host migrate into
the transplanted heart.
Clinical outcome of a cohort
of patients eligible for therapeutic angiogenesis or transmyocardial
revascularization
Mukherjee D, et al.
Am Heart J 2001;142:72-4
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11431659
The patients ineligible for traditional methods of revascularization had a
rehospitalization rate of 128%, a 25.5% rate of myocardial infarction, and a
mortality rate of 16.9%. The prognosis of many patients eligible for newer
methods of revascularization on maximal medical therapy is poor.
Angiogenesis therapy: amidst
the hype, the neglected potential for serious side effects
Epstein SE, et al.
Circulation 2001;104:115-9
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11435348
Images in Cardiology
Histological Evidence of Angiogenesis 9 Months After Transmyocardial Laser
Revascularization
Domkowski PW ||Lowe JE
Circulation 2001;103 469-471
http://circ.ahajournals.org/cgi/content/full/103/3/469
Percutaneous transmyocardial
laser revascularisation
Harbison J, et al.
Lancet 2001;357:638-9
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11558518
Sustained angina relief 5
years after transmyocardial laser revascularization with a CO(2) laser
Horvath KA, et al.
Circulation 2001;104:I81-4
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11568035
Surgical and percutaneous
myocardial angiogenesis induction. Part II--neoangiogenesis
Gimelli G, et al.
Ital Heart J 2001;2:21-4
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11214697
Review
Therapeutic angiogenesis for cardiovascular disease
Yin-Shan Ng, Patricia A D'Amore
http://cvm.controlled-trials.com/content/2/6/278
Transmyocardial laser
revascularization: is the enthusiasm justified?
Hayat N, et al.
Clin Cardiol 2001;24:321-4
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11303701
Transmyocardial laser revascularization is associated with significant relief of
angina pectoris in the majority of patients with severe diffuse coronary artery
disease; however, this relief is short-lived in most. When mortality and
morbidity are factored in, TMLR cannot be enthusiastically recommended.
Online myocardial viability
assessment in the catheterization laboratory via NOGA electroanatomic mapping:
Quantitative comparison with thallium-201 uptake
Gyongyosi M, et al.
Circulation 2001;104:1005-11
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11524393
These study indicates that the unipolar voltage potentials obtained by
electroanatomic mapping correlate well with standard quantitative late resting
(201)Tl imaging for the evaluation of myocardial viability; thus, NOGA
endocardial mapping provides useful "online" data at the time of
catheterization, especially when information from other methods for viability
assessment is unavailable.
Evidence that human cardiac
myocytes divide after myocardial infarction
Beltrami AP, et al.
N Engl J Med 2001;344:1750-7
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11396441
The results of this study challenge the dogma that the adult heart is a
postmitotic organ and indicate that the regeneration of myocytes may be a
critical component of the increase in muscle mass of the myocardium. Human
hearts after extensive MI have a significant number of cardiomyocytes engaged in
cell cycling near the infarct, suggestive of cell proliferation.
This challenges the view that the human heart does not regenerate http://www.theheart.org/index.cfm?doc_id=23473
Cellular therapy reverses
myocardial dysfunction
Rajnoch C, et al.
J Thorac Cardiovasc Surg 2001;121:871-8
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11326230
Read Comment
Commentary
Cellular cardiomyoplasty with autologous skeletal myoblasts for ischemic
heart disease and heart failure
Doris A Taylor
Curr Control Trials Cardiovasc Med 2001, 2
Click here to read the article
Cardiovascular News
Myocyte Implants Appear Feasible and Safe
Ruth SoRelle
Circulation 2001;104 e9056
http://circ.ahajournals.org/cgi/content/full/104/23/e9056
Is skeletal myoblast
transplantation clinically relevant in the era of angiotensin-converting enzyme
inhibitors?
Pouzet B, et al.
Circulation 2001;104:I223-8
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11568060
Stem cell therapy: what
cardiologists need to know
http://www.theheart.org/index.cfm?doc_id=25158
Sep 07, 2001. Stem cell research has been vigorously debated in the media
recently, and major advances have been reported regarding the therapeutic use of
embryonic and adult stem cells. Three cardiovascular researchers, Drs Robert
Roberts, Piero Anversa, and Seigo Izumo, came together to
discuss stem cell therapy from a cardiologist's point of view, just 3 days
before US President Bush announced federal funding for research involving
existing embryonic stem cell lines.
Bone marrow cells regenerate
infarcted myocardium
Orlic D, et al.
Nature 2001;410:701-5
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11287958
Implantation of bone marrow
mononuclear cells into ischemic myocardium enhances collateral perfusion and
regional function via side supply of angioblasts, angiogenic ligands, and
cytokines
Kamihata H, et al.
Circulation 2001;104:1046-52
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11524400
Bone marrow implantation was shown to enhance angiogenesis in a rat
ischemic heart model. This preclinical study using a swine model suggests that
bone marrow implantation may constitute a novel safety strategy for achieving
optimal therapeutic angiogenesis by the natural ability of the bone marrow cells
to secrete potent angiogenic ligands and cytokines as well as to be incorporated
into foci of neovascularization.
Neovascularization of ischemic
myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte
apoptosis, reduces remodeling and improves cardiac function
Kocher AA, et al.
Nat Med 2001;7:430-6
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11283669
Intracoronary, human
autologous stem cell transplantation for myocardial regeneration following
myocardial infarction
Strauer BE, et al.
Dtsch Med Wochenschr 2001;126:932-8
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11523014
Oct 16, 2001 A German cardiologist has successfully treated an MI patient
with his own stem cells for the first time. His team reported a significant
improvement of the patient's heart function after the procedure. The news caused
quite a stir at the XXIII Congress of the European Society of Cardiology, and
the cardiologist hopes to present his results at the AHA meeting in November
2001
http://www.theheart.org/documents/page.cfm?from=590001200&doc_id=25482
TCT 2000 Expert Presentation Slides
Review
Basic principles of angiogenesis for the interventional cardiologist
Andrew P Levy and Ariel Roguin
Int J Cardiovasc Intervent 2000; 3: 13–19
Click here to view the full article
This review summarizes the physiology of angiogenesis and gives an update on the current available trials data of angiogenic cytokines administration
Review
Catheter-based transendocardial gene delivery for therapeutic myocardial angiogenesis
Kornowski R et al.
Int J Cardiovasc Intervent 2000; 3:67-70
This report reviews the rationale and current experience of using a catheter-based approach as a promising platform for proangiogenic intramyocardial gene delivery strategy
Surgical and percutaneous myocardial angiogenesis induction. Part I-- laser revascularization
Gimelli G et al.
Ital Heart J 2000;1:785-94
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0011152409
Click here to view the full article
In the first part of this article, the Authors review laser- induced direct myocardial
revascularization, its indications, potential risks, and published clinical
trials.
Intracoronary basic fibroblast growth factor (FGF-2) in patients with severe ischemic heart disease: results of a phase I open-label dose escalation study
Laham RJ et al.
J Am Coll Cardiol 2000;36:2132-9
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0011127452
Intracoronary administration of rFGF-2 appears safe and is well tolerated over a 100-fold dose range (0.33 to 48
microk/kg). Preliminary evidence of efficacy is tempered by the open-label uncontrolled design of the
study.
Short- and intermediate-term clinical outcomes from direct myocardial laser revascularization guided by biosense left ventricular electromechanical mapping
Kornowski R et al.
Circulation 2000;102:1120-5
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010973840actoids
Click here to view the slide
Percutaneous DMR guided by left ventricular mapping is feasible and safe and reveals improved angina and prolonged exercise duration for up to a 6-month
follow-up.
Late-Breaking Clinical Trial
DIRECT Trial (DMR In Regeneration of Endomyocardial Channels Trial)
Leon MB Presented at the TCT 2000 Meeting
Percutaneous DMR: No Better Than Placebo - Direct myocardial revascularization performed percutaneously with a laser, long studied as a last-ditch measure for angina patients who have no other treatment
options, was no better than a placebo in a major randomized trial. Unless other controlled studies can prove DMR
works, says the Martin Leon, M.D., the principal investigator of DIRECT, "I would wonder how clinical operators and surgeons in good conscience could continue performing this procedure."
Click here to view the full
article.
Click here or here for the slide set presented at TCT 2000.
PACIFIC Trial Percutaneous transmyocardial laser revascularisation for severe angina. Potential Class Improvement From Intramyocardial Channels
Lancet 2000;356:1705-10
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0011095257
In this trial, 221 patients with severe angina were randomized to continued medical treatment or percutaneous transmyocardial laser revascularization
(PTMR). At one year, exercise tolerance had improved by 89.0 seconds in the PTMR group compared with 12.5 seconds in the control
group. (p=0.008). By this time, there were 8 deaths in the PTMR group and 3 in the medical
group. Trial News for Tuesday, November 21, 2000
Technical delivery of myogenic cells through an endocardial injection catheter for myocardial cell implantation
Uri Oron; Orna Halevy; Tali Yaakobi; Gal Hayam; Lior Gepstein; Tamir
Wolf; Shlomo Ben-Haim
International Journal of Cardiovascular Interventions Volume 3 Number 4 December 2000 Page 227
Oron and colleagues present a paper that deals with techniques for injection of myogenic cells into the
myocardium. While the principles of cellular molecular treatment of the heart can be studied in theory and
practice, the practicality of this treatment will have to be developed by the device
industry. The platform for such treatment leads in multiple directions, involving
angiogenesis, and myocardial transplantation with a variety of cell sources. A common catheter for all these cellular technique is under
development.
Immediate effect of Biosense guided
percutaneous direct myocardial revascularization with holmium:yttrium aluminium
garnet laser on myocardial contractility assessed by transesophageal
echocardiography
Shiran A, et al.
Coron Artery Dis 2000;11:359-61.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10860180
Delivery strategies to achieve therapeutic
myocardial angiogenesis
Kornowski R, et al.
Circulation 2000;101:454-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10653839
http://www.circulationaha.org/cgi/content/full/101/4/454
Electromagnetic guidance for catheter-based
transendocardial injection: a platform for intramyocardial angiogenesis therapy.
Results in normal and ischemic porcine models
Kornowski R, et al.
J Am Coll Cardiol 2000;35:1031-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10732905
Percutaneous transmyocardial laser
revascularization: overview of US clinical trials
Kornowski R, et al.
Semin Interv Cardiol 2000;5:97-101.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10867767
Short- and intermediate-term clinical
outcomes from direct myocardial laser revascularization guided by biosense left
ventricular electromechanical mapping
Kornowski R, et al.
Circulation 2000;102:1120-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10973840
http://www.circulationaha.org/cgi/content/full/102/10/1120
Percutaneous transmyocardial laser
revascularization: an overview
Kornowski R, et al.
Catheter Cardiovasc Interv 1999;47:354-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10402297
Evaluation of the acute and chronic safety of
the biosense injection catheter system in porcine hearts
Kornowski R, et al.
Catheter Cardiovasc Interv 1999;48:447-53; discussion 454-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10559830
Left Ventricular Mapping and Myocardial
Revascularization
Kornowski R, et al.
Curr Interv Cardiol Rep 1999;1:117-126.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=11096616
Mechanical Approaches for Myocardial
Angiogenesis
Kornowski R, et al.
Curr Interv Cardiol Rep 1999;1:199-204.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=11096625
Perioperative morbidity and mortality after
transmyocardial laser revascularization: incidence and risk factors for adverse
events
Hughes GC, et al.
J Am Coll Cardiol 1999;33:1021-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10091830
Neointimal growth can be influenced by local
adventitial gene manipulation via a needle injection catheter
Huehns TY, et al.
Atherosclerosis 1999;144:135-50.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10381287
The transmyocardial laser revascularization
international registry report
Burns SM, et al.
Eur Heart J 1999;20:31-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10075139
Transmyocardial laser revascularization: early
results and 1-year follow-up
Agarwal R, et al.
Ann Thorac Surg 1999;67:432-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10197665
Current status of transmyocardial laser
revascularization: review of the literature
Abramov D, et al.
Can J Cardiol 1999;15:303-10.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10202194
In vitro growth suppression of vascular smooth
muscle cells using adenovirus-mediated gene transfer of a truncated form of
fibroblast growth factor receptor
Yukawa H, et al.
Atherosclerosis 1998;141:125-32.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9863545
Angiogenesis is enhanced in ischemic canine
myocardium by transmyocardial laser revascularization
Yamamoto N, et al.
J Am Coll Cardiol 1998;31:1426-33.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9581745
Effect of basic fibroblast growth factor on
angiogenesis in the infarcted porcine heart
Watanabe E, et al.
Basic Res Cardiol 1998;93:30-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9538935
Local adenovirus-mediated transfer of human
endothelial nitric oxide synthase reduces luminal narrowing after coronary
angioplasty in pigs
Varenne O, et al.
Circulation 1998;98:919-26.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9738648
Potentiated angiogenic effect of scatter factor/hepatocyte
growth factor via induction of vascular endothelial growth factor: the case for
paracrine amplification of angiogenesis
Van Belle E, et al.
Circulation 1998;97:381-90.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9468212
Transmyocardial laser as an adjunct to
minimally invasive CABG for complete myocardial revascularization
Trehan N, et al.
Ann Thorac Surg 1998;66:1113-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9769015
Early coronary angiogenesis in response to
thyroxine: growth characteristics and upregulation of basic fibroblast growth
factor
Tomanek RJ, et al.
Circ Res 1998;82:587-93.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9529163
Gene therapy for vascular disease
Svensson EC, et al.
Curr Opin Cardiol 1998;13:369-74.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9823792
Increased vulnerability of neurones and glial
cells to low concentrations of methylmercury in a prooxidant situation
Sorg O, et al.
Acta Neuropathol (Berl) 1998;96:621-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9845292
Transmyocardial laser revascularization: three
sequential autopsy cases
Sigel JE, et al.
J Thorac Cardiovasc Surg 1998;115:1381-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9628684
Induction of neoangiogenesis in ischemic
myocardium by human growth factors: first clinical results of a new treatment of
coronary heart disease
Schumacher B, et al.
Circulation 1998;97:645-50.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9495299
Fas ligand gene transfer to the vessel wall
inhibits neointima formation and overrides the adenovirus-mediated T cell
response
Sata M, et al.
Proc Natl Acad Sci U S A 1998;95:1213-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9448311
Insertion/deletion polymorphism of the
angiotensin I-converting enzyme gene is associated with coronary artery plaque
calcification as assessed by intravascular ultrasound
Pfohl M, et al.
J Am Coll Cardiol 1998;31:987-91.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9561998
Thoracoscopic transmyocardial revascularization
Milano A, et al.
Ann Thorac Surg 1998;65:1510-1.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9594909
Early results of transmyocardial
revascularization with a holmium laser
Milano A, et al.
Ann Thorac Surg 1998;65:700-4.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9527198
Transmyocardial revascularization for cardiac
transplantation allograft vasculopathy
McFadden PM, et al.
J Thorac Cardiovasc Surg 1998;115:1385-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9628685
Biologic bypass with the use of
adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for
vascular endothelial growth factor 121 improves myocardial perfusion and
function in the ischemic porcine heart
Mack CA, et al.
J Thorac Cardiovasc Surg 1998;115:168-76; discussion 176-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9451061
Salvage angiogenesis induced by
adenovirus-mediated gene transfer of vascular endothelial growth factor protects
against ischemic vascular occlusion
Mack CA, et al.
J Vasc Surg 1998;27:699-709.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9576084
Histologic findings of transmyocardial laser
channels after two hours
Lutter G, et al.
Ann Thorac Surg 1998;65:1437-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9594881
Angiogenic potential of perivascularly
delivered aFGF in a porcine model of chronic myocardial ischemia
Lopez JJ, et al.
Am J Physiol 1998;274:H930-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9530206
National Diabetes Education Program:
opportunities and challenges. The National Diabetes Education Program Strategic
Planning Committee
Leontos C, et al.
J Am Diet Assoc 1998;98:73-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9434654
Transmyocardial revascularization: mechanism of
action with carbon dioxide and holmium-yttrium-aluminum-garnet lasers
Lansing AM.
J Thorac Cardiovasc Surg 1998;115:1392.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9628690
Current perspectives on direct myocardial
revascularization
Kornowski R, et al.
Am J Cardiol 1998;81:44E-48E.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9551594
Feasibility and safety of percutaneous laser
revascularization using the Biosense system in porcine hearts
Kornowski R, et al.
Coron Artery Dis 1998;9:535-40
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9847986
Evidence of vascular growth associated with
laser treatment of normal canine myocardium
Kohmoto T, et al.
Ann Thorac Surg 1998;65:1360-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9594867
Angiopoietin-1 induces sprouting angiogenesis
in vitro
Koblizek TI, et al.
Curr Biol 1998;8:529-32.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9560344
http://www.biomednet.com/article/bb8i51
Human endothelial nitric oxide synthase gene
transfer inhibits vascular smooth muscle cell proliferation and neointima
formation after balloon injury in rats
Janssens S, et al.
Circulation 1998;97:1274-81.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9570198
Combined TMR and mitral valve replacement via
left thoracotomy
Hughes GC, et al.
Ann Thorac Surg 1998;65:1141-3.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9564947
Thoracoscopic transmyocardial laser
revascularization
Horvath KA.
Ann Thorac Surg 1998;65:1439-41.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9594882
Left ventricular functional improvement after
transmyocardial laser revascularization
Horvath KA, et al.
Ann Thorac Surg 1998;66:721-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9768921
Transmyocardial laser revascularization in
allograft coronary artery disease
Frazier OH, et al.
Ann Thorac Surg 1998;65:1138-41.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9564946
Current status of percutaneous transmyocardial
revascularisation
Bhargava B, et al.
Indian Heart J 1998;50 Suppl 1:130-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9824918
Constitutive expression of phVEGF165 after
intramuscular gene transfer promotes collateral vessel development in patients
with critical limb ischemia
Baumgartner I, et al.
Circulation 1998;97:1114-23.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9537336
Monocyte activation in angiogenesis and
collateral growth in the rabbit hindlimb
Arras M, et al.
J Clin Invest 1998;101:40-50.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9421464
Downregulation of cyclin G1 expression by
retrovirus-mediated antisense gene transfer inhibits vascular smooth muscle cell
proliferation and neointima formation
Zhu NL, et al.
Circulation 1997;96:628-35.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9244236
Modulation of growth factor action:
implications for the treatment of cardiovascular diseases
Waltenberger J.
Circulation 1997;96:4083-94.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9403634
Passivation of metallic stents after arterial
gene transfer of phVEGF165 inhibits thrombus formation and intimal thickening
Van Belle E, et al.
J Am Coll Cardiol 1997;29:1371-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9137238
Hypercholesterolemia attenuates angiogenesis
but does not preclude augmentation by angiogenic cytokines
Van Belle E, et al.
Circulation 1997;96:2667-74.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9355908
Adenovirus-mediated expression of the secreted
form of basic fibroblast growth factor (FGF-2) induces cellular proliferation
and angiogenesis in vivo
Ueno H, et al.
Arterioscler Thromb Vasc Biol 1997;17:2453-60.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9409215
Transfection of human endothelial cells
Tanner FC, et al.
Cardiovasc Res 1997;35:522-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9415297
The Dispatch catheter as a delivery tool for
arterial gene transfer
Tahlil O, et al.
Cardiovasc Res 1997;33:181-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9059542
Arterial gene transfer of acidic fibroblast
growth factor for therapeutic angiogenesis in vivo: critical role of secretion
signal in use of naked DNA
Tabata H, et al.
Cardiovasc Res 1997;35:470-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9415291
Transmyocardial laser revascularization for
inoperable coronary artery disease
Sundt TM, 3rd, et al.
Curr Opin Cardiol 1997;12:441-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9352170
Reduction of restenosis after angioplasty in an
atheromatous rabbit model by suicide gene therapy
Steg PG, et al.
Circulation 1997;96:408-11.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9244204
Effect of basic fibroblast growth factor on
myocardial angiogenesis in dogs with mature collateral vessels
Shou M, et al.
J Am Coll Cardiol 1997;29:1102-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9120166
Efficient gene transfer method into the whole
heart through the coronary artery with hemagglutinating virus of Japan liposome
Sawa Y, et al.
J Thorac Cardiovasc Surg 1997;113:512-8; discussion 518-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9081096
Therapeutic angiogenesis: a comparative study
of the angiogenic potential of acidic fibroblast growth factor and heparin
Rosengart TK, et al.
J Vasc Surg 1997;26:302-12.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9279319
Endoluminal local delivery of PCNA/cdc2
antisense oligonucleotides by porous balloon catheter does not affect neointima
formation or vessel size in the pig coronary artery model of postangioplasty
restenosis
Robinson KA, et al.
Cathet Cardiovasc Diagn 1997;41:348-53.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9213035
Pharmacokinetics and tissue localization of
antisense oligonucleotides in balloon-injured pig coronary arteries after local
delivery with an iontophoretic balloon catheter
Robinson KA, et al.
Cathet Cardiovasc Diagn 1997;41:354-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9213036
Transmyocardial laser revascularization using a
thoracoscopic approach
Milano A, et al.
Am J Cardiol 1997;80:538-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9285680
Management of cardiac allograft vasculopathy by
transmyocardial laser revascularization
Malik FS, et al.
Am J Cardiol 1997;80:224-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9230169
Angiopoietin-2, a natural antagonist for Tie2
that disrupts in vivo angiogenesis
Maisonpierre PC, et al.
Science 1997;277:55-60.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9204896
Regional angiogenesis induced in nonischemic
tissue by an adenoviral vector expressing vascular endothelial growth factor
Magovern CJ, et al.
Hum Gene Ther 1997;8:215-27.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9017425
Channel patency and neovascularization after
transmyocardial revascularization using an excimer laser: results and
comparisons to nonlased channels
Mack CA, et al.
Circulation 1997;96:II-65-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9386077
Vascular endothelial growth factor attenuates
myocardial ischemia- reperfusion injury
Luo Z, et al.
Ann Thorac Surg 1997;64:993-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9354516
Hemodynamic effects of intracoronary VEGF
delivery: evidence of tachyphylaxis and NO dependence of response
Lopez JJ, et al.
Am J Physiol 1997;273:H1317-23.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9321821
Basic fibroblast growth factor in a porcine
model of chronic myocardial ischemia: a comparison of angiographic,
echocardiographic and coronary flow parameters
Lopez JJ, et al.
J Pharmacol Exp Ther 1997;282:385-90.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9223578
Stretch-induced VEGF expression in the heart
Li J, et al.
J Clin Invest 1997;100:18-24.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9202052
Pharmacodynamics of basic fibroblast growth
factor: route of administration determines myocardial and systemic distribution
Lazarous DF, et al.
Cardiovasc Res 1997;36:78-85.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9415275
Transmyocardial laser treatment denervates
canine myocardium
Kwong KF, et al.
J Thorac Cardiovasc Surg 1997;114:883-9; discussion 889-90.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9434682
Physiology, histology, and 2-week morphology of
acute transmyocardial channels made with a CO2 laser
Kohmoto T, et al.
Ann Thorac Surg 1997;63:1275-83.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9146314
Percutaneous method of laser transmyocardial
revascularization
Kim CB, et al.
Cathet Cardiovasc Diagn 1997;40:223-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9047073
Laser-tissue interaction during transmyocardial
laser revascularization
Jansen ED, et al.
Ann Thorac Surg 1997;63:640-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9066377
Monocyte chemotactic protein-1 increases
collateral and peripheral conductance after femoral artery occlusion
Ito WD, et al.
Circ Res 1997;80:829-37.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9168785
Angiogenesis but not collateral growth is
associated with ischemia after femoral artery occlusion
Ito WD, et al.
Am J Physiol 1997;273:H1255-65.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9321814
Transmyocardial laser revascularization:
results of a multicenter trial with transmyocardial laser revascularization used
as sole therapy for end-stage coronary artery disease
Horvath KA, et al.
J Thorac Cardiovasc Surg 1997;113:645-53; discussion 653-4.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9104973
Inhibition of vascular smooth muscle cell
proliferation and neointimal accumulation by adenovirus-mediated gene transfer
of cytosine deaminase
Harrell RL, et al.
Circulation 1997;96:621-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9244235
The effect of oligonucleotides to c-myb on
vascular smooth muscle cell proliferation and neointima formation after porcine
coronary angioplasty
Gunn J, et al.
Circ Res 1997;80:520-31.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9118483
Cerebral embolization during transmyocardial
laser revascularization
Grocott HP, et al.
J Thorac Cardiovasc Surg 1997;114:856-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9375621
Transmyocardial laser revascularization.
Histological features in human nonresponder myocardium
Gassler N, et al.
Circulation 1997;95:371-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9008451
Histologic analysis of transmyocardial channels:
comparison of CO2 and holmium:YAG lasers
Fisher PE, et al.
Ann Thorac Surg 1997;64:466-72.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9262595
Improvement in inducible ischemia during
dobutamine stress echocardiography after transmyocardial laser revascularization
in patients with refractory angina pectoris
Donovan CL, et al.
J Am Coll Cardiol 1997;30:607-12.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9283515
Thoracoscopic transmyocardial laser
revascularization
deGuzman BJ, et al.
Ann Thorac Surg 1997;64:171-4.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9236355
Patient care and expectations for recovery
after transmyocardial laser revascularization
Carlson PC.
AACN Clin Issues 1997;8:33-40.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9086915
Pseudovascular tubes obscure transmyocardial
revascularization
Beranek JT.
Ann Thorac Surg 1997;63:597-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9033359
Local delivery of c-myb antisense
oligonucleotides during balloon angioplasty
Azrin MA, et al.
Cathet Cardiovasc Diagn 1997;41:232-40.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9213020
Isolation of putative progenitor endothelial
cells for angiogenesis
Asahara T, et al.
Science 1997;275:964-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9020076
Improved bioresorbable microporous
intravascular stents for gene therapy
Ye YW, et al.
Asaio J 1996;42:M823-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8944998
Transmyocardial revascularisation
Wistow T, et al.
Heart 1996;76:191-2.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8868972
Transmural channels can protect ischemic tissue.
Assessment of long- term myocardial response to laser- and needle-made channels
Whittaker P, et al.
Circulation 1996;93:143-52.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8616921
Functional upregulation of the vascular
endothelial growth factor receptor KDR by hypoxia
Waltenberger J, et al.
Circulation 1996;94:1647-54.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8840857
Direct intramuscular gene transfer of naked DNA
encoding vascular endothelial growth factor augments collateral development and
tissue perfusion
Tsurumi Y, et al.
Circulation 1996;94:3281-90.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8989142
Transmyocardial laser revascularisation as an
adjunct to CABG
Trehan N, et al.
Indian Heart J 1996;48:381-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8908826
Therapeutic angiogenesis following arterial
gene transfer of vascular endothelial growth factor in a rabbit model of
hindlimb ischemia
Takeshita S, et al.
Biochem Biophys Res Commun 1996;227:628-35.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8878563
Gene transfer of naked DNA encoding for three
isoforms of vascular endothelial growth factor stimulates collateral development
in vivo
Takeshita S, et al.
Lab Invest 1996;75:487-501.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8874381
Requisite role of angiopoietin-1, a ligand for
the TIE2 receptor, during embryonic angiogenesis
Suri C, et al.
Cell 1996;87:1171-80.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8980224
Enhanced microvascular relaxations to VEGF and
bFGF in chronically ischemic porcine myocardium
Sellke FW, et al.
Am J Physiol 1996;271:H713-20.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8770115
Trends and strategies for myocardial
revascularization
Schmid C, et al.
Thorac Cardiovasc Surg 1996;44:113-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8858792
Therapeutic targets in cardiovascular disorders
Schaper W, et al.
Curr Opin Biotechnol 1996;7:635-40.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8939638
Transmyocardial laser revascularization and
coronary artery bypass grafting without cardiopulmonary bypass
Saatvedt K, et al.
Ann Thorac Surg 1996;62:323-4.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8678682
Ischemic/reperfused myocardium can express
recombinant protein following direct DNA or retroviral injection
Prentice H, et al.
J Mol Cell Cardiol 1996;28:133-40.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8745221
Processing of chimeric antisense
oligonucleotides by human vascular smooth muscle cells and human atherosclerotic
plaque. Implications for antisense therapy of restenosis after angioplasty
Pickering JG, et al.
Circulation 1996;93:772-80.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8641007
Molecular biology and post-angioplasty
restenosis
Nikol S, et al.
Atherosclerosis 1996;123:17-31.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8782834
Proliferation, migration, matrix turnover, and
death of smooth muscle cells in native coronary and vein graft atherosclerosis
Newby AC, et al.
Curr Opin Cardiol 1996;11:574-82.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8968671
Safety and efficacy of in vivo gene transfer
into the porcine heart with replication-deficient, recombinant adenovirus
vectors
Muhlhauser J, et al.
Gene Ther 1996;3:145-53.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8867862
Attacking heart disease with novel molecular
tools
Marks AR.
Bull N Y Acad Med 1996;73:25-36.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8804735
Direct in vivo gene transfer to canine
myocardium using a replication- deficient adenovirus vector
Magovern CJ, et al.
Ann Thorac Surg 1996;62:425-33; discussion 433-4.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8694601
VEGF, flk-1, and flt-1 expression in a rat
myocardial infarction model of angiogenesis
Li J, et al.
Am J Physiol 1996;270:H1803-11.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8928889
Adenovirus-mediated gene transfer into
infarcted myocardium: feasibility, timing, and location of expression
Leor J, et al.
J Mol Cell Cardiol 1996;28:2057-67.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8930802
Cardiac gene transfer by intracoronary infusion
of adenovirus vector- mediated reporter gene in the transplanted mouse heart
Lee J, et al.
J Thorac Cardiovasc Surg 1996;111:246-52.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8551772
Comparative effects of basic fibroblast growth
factor and vascular endothelial growth factor on coronary collateral development
and the arterial response to injury
Lazarous DF, et al.
Circulation 1996;94:1074-82.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8790049
Transmyocardial revascularization for
intractable angina
Lansing AM, et al.
J Ky Med Assoc 1996;94:432-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8908945
Histological findings after transmyocardial
laser revascularization
Krabatsch T, et al.
J Card Surg 1996;11:326-31.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8969377
Long-term gene transfer in porcine myocardium
after coronary infusion of an adeno-associated virus vector
Kaplitt MG, et al.
Ann Thorac Surg 1996;62:1669-76.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8957370
Clinical evidence of angiogenesis after
arterial gene transfer of phVEGF165 in patient with ischaemic limb
Isner JM, et al.
Lancet 1996;348:370-4.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8709735
Reduction in myocardial infarct size by basic
fibroblast growth factor after temporary coronary occlusion in a canine model
Horrigan MC, et al.
Circulation 1996;94:1927-33.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8873670
Vascular endothelial growth factor
administration in chronic myocardial ischemia
Harada K, et al.
Am J Physiol 1996;270:H1791-802.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8928888
Molecular genetics as the route to
understanding, prevention, and treatment
Hamsten A.
Lancet 1996;348 Suppl 1:s17-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8918523
Intracoronary gene transfer of fibroblast
growth factor-5 increases blood flow and contractile function in an ischemic
region of the heart
Giordano FJ, et al.
Nat Med 1996;2:534-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8616711
Transmyocardial laser revascularization
Frazier OH, et al.
Curr Opin Cardiol 1996;11:564-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8968669
Perspectives of arterial gene therapy for the
prevention of restenosis
Feldman LJ, et al.
Cardiovasc Res 1996;32:194-207.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8796105
Fusigenic viral liposome for gene therapy in
cardiovascular diseases
Dzau VJ, et al.
Proc Natl Acad Sci U S A 1996;93:11421-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8876150
Gene therapy for donor hearts: ex vivo
liposome-mediated transfection
Dalesandro J, et al.
J Thorac Cardiovasc Surg 1996;111:416-21; discussion 421-2.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8583815
Transmyocardial laser revascularization:
clinical experience with twelve-month follow-up
Cooley DA, et al.
J Thorac Cardiovasc Surg 1996;111:791-7; discussion 797-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8614139
Histologic appearance of transmyocardial laser
channels after 4 1/2 weeks
Burkhoff D, et al.
Ann Thorac Surg 1996;61:1532-4; discussion 1534-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8633979
Antisense knockout of a neuropeptide gene
reduces fibroblast proliferation
Weisinger G, et al.
Biochem Biophys Res Commun 1995;214:530-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7677762
Effects of antisense c-myb oligonucleotides on
vascular smooth muscle cell proliferation and response to vessel wall injury
Villa AE, et al.
Circ Res 1995;76:505-13.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7895327
Angiogenic therapy of acute myocardial
infarction by intrapericardial injection of basic fibroblast growth factor and
heparin sulfate: an experimental study
Uchida Y, et al.
Am Heart J 1995;130:1182-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7484767
The phantom of "myocardial sinusoids":
a historical reappraisal
Tsang JC, et al.
Ann Thorac Surg 1995;60:1831-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8787502
Molecular cardiomyoplasty: potential cardiac
gene therapy for chronic heart failure
Tam SK, et al.
J Thorac Cardiovasc Surg 1995;109:918-23; discussion 923-4.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7739253
Transmyocardial laser revascularization
Smith JA, et al.
J Card Surg 1995;10:569-72.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7488780
Efficiency of in vivo gene transfection into
transplanted rat heart by coronary infusion of HVJ liposome
Sawa Y, et al.
Circulation 1995;92:II479-82.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7586458
Potential gene therapy strategies in the
treatment of cardiovascular disease
Rowland RT, et al.
Ann Thorac Surg 1995;60:721-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7677519
An appraisal of dipyridamole thallium
imaging-detected ischemia in Chinese following acute myocardial infarction
Pan JP, et al.
Chung Hua I Hsueh Tsa Chih (Taipei) 1995;55:225-34.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7780879
In vivo angiogenesis induced by recombinant
adenovirus vectors coding either for secreted or nonsecreted forms of acidic
fibroblast growth factor
Muhlhauser J, et al.
Hum Gene Ther 1995;6:1457-65.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8573618
VEGF165 expressed by a replication-deficient
recombinant adenovirus vector induces angiogenesis in vivo
Muhlhauser J, et al.
Circ Res 1995;77:1077-86.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7586219
Genetic engineering of vein grafts resistant to
atherosclerosis
Mann MJ, et al.
Proc Natl Acad Sci U S A 1995;92:4502-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7753833
Effects of chronic systemic administration of
basic fibroblast growth factor on collateral development in the canine heart
Lazarous DF, et al.
Circulation 1995;91:145-53.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7805195
Intrapericardial basic fibroblast growth factor
induces myocardial angiogenesis in a rabbit model of chronic ischemia
Landau C, et al.
Am Heart J 1995;129:924-31.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7537443
Which gene for which restenosis?
Lafont A, et al.
Lancet 1995;346:1442-3.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7490986
Correlation of rates of coronary artery bypass
surgery, angioplasty, and cardiac catheterization in 305 large communities for
persons age 65 and older
Kuhn EM, et al.
Health Serv Res 1995;30:425-36.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7649750
Insulin-like growth factor I is involved in
inflammation linked angiogenic processes after microembolisation in porcine
heart
Kluge A, et al.
Cardiovasc Res 1995;29:407-15.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7540112
Arterial gene therapy for therapeutic
angiogenesis in patients with peripheral artery disease
Isner JM, et al.
Circulation 1995;91:2687-92.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7538919
Recovery and viability of an acute myocardial
infarct after transmyocardial laser revascularization
Horvath KA, et al.
J Am Coll Cardiol 1995;25:258-63.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7798512
Recent advances in the application of gene
therapy to human disease
Hanania EG, et al.
Am J Med 1995;99:537-52.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7485213
The influence of race on the use of surgical
procedures for treatment of peripheral vascular disease of the lower extremities
Guadagnoli E, et al.
Arch Surg 1995;130:381-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7710336
Small area variations in health care delivery
in Maryland
Gittelsohn A, et al.
Health Serv Res 1995;30:295-317.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7782218
Race and sex differences in rates of invasive
cardiac procedures in US hospitals. Data from the National Hospital Discharge
Survey
Giles WH, et al.
Arch Intern Med 1995;155:318-24.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7832604
Inhibition of intravascular thrombosis and
vascular smooth muscle cell proliferation by gene therapy
Flugelman MY.
Thromb Haemost 1995;74:406-10.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8578496
Gene therapy for vascular disease
Finkel T, et al.
Faseb J 1995;9:843-51.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7615154
Low-efficiency of percutaneous
adenovirus-mediated arterial gene transfer in the atherosclerotic rabbit
Feldman LJ, et al.
J Clin Invest 1995;95:2662-71.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7769106
Prevention of restenosis after coronary
angioplasty: towards a molecular approach?
Feldman LJ, et al.
Fundam Clin Pharmacol 1995;9:8-16
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7768490
Gene therapy for the vulnerable plaque
Feldman LJ, et al.
J Am Coll Cardiol 1995;26:826-35.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7642878
Molecular biology of graft occlusion
Callow AD.
Curr Opin Cardiol 1995;10:569-76.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8573976
The antiproliferative activity of c-myb and
c-myc antisense oligonucleotides in smooth muscle cells is caused by a
nonantisense mechanism
Burgess TL, et al.
Proc Natl Acad Sci U S A 1995;92:4051-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7732029
Access to hospitals with high-technology
cardiac services: how is race important?
Blustein J, et al.
Am J Public Health 1995;85:345-51.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7892917
Antisense therapy for angioplasty restenosis.
Some critical considerations
Bennett MR, et al.
Circulation 1995;92:1981-93.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7671381
Site-specific therapeutic angiogenesis after
systemic administration of vascular endothelial growth factor
Bauters C, et al.
J Vasc Surg 1995;21:314-24; discussion 324-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7531786
Recovery of disturbed endothelium-dependent
flow in the collateral- perfused rabbit ischemic hindlimb after administration
of vascular endothelial growth factor
Bauters C, et al.
Circulation 1995;91:2802-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7758187
Gene therapy for cardiovascular diseases
Bauters C.
Eur Heart J 1995;16:1166-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8582376
Antisense oligonucleotides to the p65 subunit
of NF-kB inhibit human vascular smooth muscle cell adherence and proliferation
and prevent neointima formation in rat carotid arteries
Autieri MV, et al.
Biochem Biophys Res Commun 1995;213:827-36.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7654244
Synergistic effect of vascular endothelial
growth factor and basic fibroblast growth factor on angiogenesis in vivo
Asahara T, et al.
Circulation 1995;92:II365-71.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7586439
Genetic modification of the vessel wall.
Comparison of surgical and catheter-based techniques for delivery of recombinant
adenovirus
Willard JE, et al.
Circulation 1994;89:2190-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8181144
Basic fibroblast growth factor enhances
myocardial collateral flow in a canine model
Unger EF, et al.
Am J Physiol 1994;266:H1588-95.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8184938
Therapeutic angiogenesis. A single
intraarterial bolus of vascular endothelial growth factor augments
revascularization in a rabbit ischemic hind limb model
Takeshita S, et al.
J Clin Invest 1994;93:662-70.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7509344
Intramuscular administration of vascular
endothelial growth factor induces dose-dependent collateral artery augmentation
in a rabbit model of chronic limb ischemia
Takeshita S, et al.
Circulation 1994;90:II228-34.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7525111
Transcatheter delivery of c-myc antisense
oligomers reduces neointimal formation in a porcine model of coronary artery
balloon injury
Shi Y, et al.
Circulation 1994;90:944-51.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8044966
Gene therapy for the treatment of restenosis
after coronary angioplasty
Rapacciuolo A, et al.
Cardiologia 1994;39:843-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7781002
Pharmacokinetics of antisense
oligodeoxyribonucleotides (cyclin B1 and CDC 2 kinase) in the vessel wall in
vivo: enhanced therapeutic utility for restenosis by HVJ-liposome delivery
Morishita R, et al.
Gene 1994;149:13-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7958977
Quantitative polymerase chain reaction (PCR) to
analyze messenger-RNA expression in tissue obtained by directional atherectomy
Koster R, et al.
Angiology 1994;45:911-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7978503
In vivo suppression of injury-induced vascular
smooth muscle cell accumulation using adenovirus-mediated transfer of the herpes
simplex virus thymidine kinase gene
Guzman RJ, et al.
Proc Natl Acad Sci U S A 1994;91:10732-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7938020
Percutaneous transluminal in vivo gene transfer
by recombinant adenovirus in normal porcine coronary arteries, atherosclerotic
arteries, and two models of coronary restenosis
French BA, et al.
Circulation 1994;90:2402-13.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7955199
Direct in vivo gene transfer into porcine
myocardium using replication- deficient adenoviral vectors
French BA, et al.
Circulation 1994;90:2414-24.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7525108
The basis of molecular strategies for treating
coronary restenosis after angioplasty
Epstein SE, et al.
J Am Coll Cardiol 1994;23:1278-88.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8176084
Cardiovascular applications of laser technology
Deckelbaum LI.
Lasers Surg Med 1994;15:315-41
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7885167
Transmyocardial laser revascularization.
Anatomic evidence of long-term channel patency
Cooley DA, et al.
Tex Heart Inst J 1994;21:220-4
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8000270
Adenovirus-mediated gene transfer of soluble
vascular cell adhesion molecule to porcine interposition vein grafts
Chen SJ, et al.
Circulation 1994;89:1922-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7514108
Mithramycin inhibits myointimal proliferation
after balloon injury of the rat carotid artery in vivo
Chen SJ, et al.
Circulation 1994;90:2468-73.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7955204
Design and application of antisense
oligonucleotides in cell culture, in vivo, and as therapeutic agents
Brysch W, et al.
Cell Mol Neurobiol 1994;14:557-68.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7621513
The biology of saphenous vein graft occlusion:
etiology and strategies for prevention
Bryan AJ, et al.
Curr Opin Cardiol 1994;9:641-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7819622
Indirect angiogenic cytokines upregulate VEGF
and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia
upregulates VEGF expression only
Brogi E, et al.
Circulation 1994;90:649-52.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8044933
Does endocardial laser revascularization induce
"pseudovascular muscle tubes"?
Beranek JT.
Ann Thorac Surg 1994;57:784-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8147672
Age, race, and gender variation in the
utilization of coronary artery bypass surgery and angioplasty in SHEP. SHEP
Cooperative Research Group. Systolic Hypertension in the Elderly Program
Bearden D, et al.
J Am Geriatr Soc 1994;42:1143-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7963199
Physiological assessment of augmented
vascularity induced by VEGF in ischemic rabbit hindlimb
Bauters C, et al.
Am J Physiol 1994;267:H1263-71.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7943370
Angiogenic-induced enhancement of collateral
blood flow to ischemic myocardium by vascular endothelial growth factor in dogs
Banai S, et al.
Circulation 1994;89:2183-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7514110
Prevention of acute regional ischemia with
endocardial laser channels
Yano OJ, et al.
Ann Thorac Surg 1993;56:46-53.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8328875
Laser-mediated transmural myocardial channels
do not salvage acutely ischemic myocardium
Whittaker P, et al.
J Am Coll Cardiol 1993;22:302-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8509555
Extracardiac to coronary anastomoses support
regional left ventricular function in dogs
Unger EF, et al.
Am J Physiol 1993;264:H1567-74.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7684575
Molecular biology and therapy of disease
Samara G, et al.
Am J Surg 1993;165:720-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8506973
Vascular smooth muscle cell proliferation:
basic investigations and new therapeutic approaches
Rosenberg RD.
Thromb Haemost 1993;70:10-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8236084
Enhanced revascularization of the ischemic limb
by angiogenic therapy
Pu LQ, et al.
Circulation 1993;88:208-15.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8319335
Recombinant fibroblast growth factor-1 promotes
intimal hyperplasia and angiogenesis in arteries in vivo
Nabel EG, et al.
Nature 1993;362:844-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7683112
Intracoronary injection of basic fibroblast
growth factor enhances angiogenesis in infarcted swine myocardium
Battler A, et al.
J Am Coll Cardiol 1993;22:2001-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7504006
Salvage of infarcted myocardium by angiogenic
action of basic fibroblast growth factor
Yanagisawa-Miwa A, et al.
Science 1992;257:1401-3.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=1382313
Antisense c-myb oligonucleotides inhibit
intimal arterial smooth muscle cell accumulation in vivo
Simons M, et al.
Nature 1992;359:67-70.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=1522889
Evidence implicating nonmuscle myosin in
restenosis. Use of in situ hybridization to analyze human vascular lesions
obtained by directional atherectomy
Leclerc G, et al.
Circulation 1992;85:543-53.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=1735150
bFGF enhances the development of the collateral
circulation after acute arterial occlusion
Chleboun JO, et al.
Biochem Biophys Res Commun 1992;185:510-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=1376988
Migratory activity of human smooth muscle cells
cultivated from coronary and peripheral primary and restenotic lesions removed
by percutaneous atherectomy
Bauriedel G, et al.
Circulation 1992;85:554-64.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=1735151
Enhanced angiogenesis and growth of collaterals
by in vivo administration of recombinant basic fibroblast growth factor in a
rabbit model of acute lower limb ischemia: dose-response effect of basic
fibroblast growth factor
Baffour R, et al.
J Vasc Surg 1992;16:181-91.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=1379646
A new method of myocardial revascularization by
laser
Okada M, et al.
Thorac Cardiovasc Surg 1991;39:1-4.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=2011841
Gene transfer into vascular cells
Nabel EG, et al.
J Am Coll Cardiol 1991;17:189B-194B.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=2016477
Direct CO2 laser "revascularization"
of the myocardium
Landreneau R, et al.
Lasers Surg Med 1991;11:35-42
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=1997778
Analysis of photoproducts, free radicals, and
particulate debris generated during in vivo argon laser myoplasty
Gal D, et al.
Lasers Surg Med 1991;11:125-32
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=1851912
Effects of acidic fibroblast growth factor on
normal and ischemic myocardium
Banai S, et al.
Circ Res 1991;69:76-85.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=1711423
Site-specific gene expression in vivo by direct
gene transfer into the arterial wall
Nabel EG, et al.
Science 1990;249:1285-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=2119055
Autocrine activities of basic fibroblast growth
factor: regulation of endothelial cell movement, plasminogen activator synthesis,
and DNA synthesis
Sato Y, et al.
J Cell Biol 1988;107:1199-205.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=3417781
Identification of the fibroblast growth factor
receptor in human vascular endothelial cells
Neufeld G, et al.
J Cell Physiol 1988;136:537-42.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=2844833
New concepts in revascularization of the
myocardium
Mirhoseini M, et al.
Ann Thorac Surg 1988;45:415-20.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=3355283
A heparin-binding angiogenic protein--basic
fibroblast growth factor-- is stored within basement membrane
Folkman J, et al.
Am J Pathol 1988;130:393-400.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=3277442