Radiation Therapy 1992-2001
ESC 2001 Meeting Coverage
TCTMD - Debates & Controversies Slide Sets
Cardiovascular Radiation Therapy V And Restenosis Forum - Slide Sets
AHA 2001 Meeting Coverage
TCTMD - Euro-PCR Slide Sets
CV Channnel - Cyberconference
Brachytherapy : A luxury ? A passing trend ? A necessity ?
Consult this exciting face to face between Dr Ron Waksman, Washington
DC and Dr William Wijns, Aalst Belgium moderated by Dr Max Amor, Essey Les Nancy,
France.
Click
here to consult archive
New Frontiers in Interventional Cardiology
Intravascular Radiation to Prevent Restenosis
Paul S. Teirstein and Richard E. Kuntz
Circulation 2001;104 2620-2626
http://circ.ahajournals.org/cgi/content/full/104/21/2620
Localized intracoronary gamma-radiation
therapy to inhibit the recurrence of restenosis after stenting
Leon MB, et al.
N Engl J Med 2001;344:250-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=11172151
Endoluminal beta-radiation therapy for the
prevention of coronary restenosis after balloon angioplasty. The Dose-Finding
Study Group
Verin V, et al.
N Engl J Med 2001;344:243-9
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11172150
Intracoronary beta radiation therapy produces a significant dose-dependent
decrease in the rate of restenosis after angioplasty. An 18-Gy dose not only
prevents the renarrowing of the lumen typically observed after successful
balloon angioplasty, but actually induces luminal enlargement
Following the publication of important Beta and Gamma Radiation articles in the New England Journal of Medicine in 2001, TCTMD has assembled expert commentary and opinions:
Comparative Efficacy of {gamma}-Irradiation
for Treatment of In-Stent Restenosis in Saphenous Vein Graft Versus Native
Coronary Artery In-Stent Restenosis: An Intravascular Ultrasound Study
Castagna MT , et al
Circulation 2001;104 3020-3022
http://circ.ahajournals.org/cgi/content/abstract/104/25/3020
Serial Intravascular Ultrasound Analysis of
the Impact of Lesion Length on the Efficacy of Intracoronary gamma-Irradiation
for Preventing Recurrent In-Stent Restenosis
Ahmed JM, et al.
Circulation 2001;103:188-191
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11208674
Brachytherapy may be less effective in longer ISR lesions because of the greater
variability and longer source-to-target distances in diffuse ISR
Serial intravascular ultrasound assessment
of the efficacy of intracoronary gamma-radiation therapy for preventing
recurrence in very long, diffuse, in-stent restenosis lesions
Ahmed JM, et al.
Circulation 2001;104:856-9
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11514368
Serial IVUS analysis shows that gamma-irradiation reduces recurrent in-stent
neointimal hyperplasia in long, diffuse ISR lesions; however, it is even more
effective when given at a higher dose.
Serial intravascular ultrasound analysis of
edge recurrence after intracoronary gamma radiation treatment of native artery
in-stent restenosis lesions
Ahmed JM, et al.
Am J Cardiol 2001;87:1145-9
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11356387
Edge recurrence after (192)Ir treatment of in-stent restenosis is the result of
neointimal hyperplasia (part of generalized treatment failure) and the absence
of radiation-induced positive remodeling.
<Review>
Intravascular ultrasound assessment of the mechanisms and results of
brachytherapy
Mintz GS, et al.
Circulation 2001;104:1320-5
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11551886
Edge stenosis and geographical miss
following intracoronary gamma radiation therapy for in-stent restenosis
Kim HS, et al.
J Am Coll Cardiol 2001;37:1026-30.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=11263603
"Black hole": echolucent
restenotic tissue after brachytherapy
Castagna MT, et al.
Circulation 2001;103:778
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11156893
Images in Cardiovascular Medicine
Edge stenosis after intracoronary radiotherapy : angiographic, intravascular,
and histological findings
Kim HS, et al.
Circulation 2001;103:2219-20
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11331266
Extent and distribution of in-stent intimal
hyperplasia and edge effect in a non-radiation stent population
Weissman NJ, et al.
Am J Cardiol 2001;88:248-52
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11472702
At 6 months, intimal hyperplasia occupied 29.3 +/- 16.2% of the stent volume on
average. Lumen loss within 2 mm of the stent edge was due primarily to intimal
proliferation. Beyond 2 mm, negative remodeling contributed more to lumen loss.
Brachytherapy for in-stent restenosis
through the internal mammary artery
Kobayashi Y, et al.
Catheter Cardiovasc Interv 2001;53:530-4
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11515008
Usefulness of intracoronary brachytherapy
for in-stent restenosis with a 188Re liquid-filled balloon
Schuhlen H, et al.
Am J Cardiol 2001;87:463-6, A7
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11179537
The objective of this randomized pilot trial with 21 patients was to evaluate
the effectiveness of a rhenium-188 liquid-filled balloon system to prevent
recurrent restenosis after percutaneous transluminal coronary angioplasty for
in-stent restenosis. A significant benefit from brachytherapy was seen at
6-month repeat angiography, as well as during the clinical follow-up of 12
months.
Late acute thrombosis after coronary
brachytherapy: when is the risk over?
Liistro F ||
Colombo A
Catheter Cardiovasc Interv 2001;54:216-8
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11590688
Prolonged antiplatelet therapy to prevent
late thrombosis after intracoronary gamma-radiation in patients with in-stent
restenosis: Washington Radiation for In-Stent Restenosis Trial plus 6 months of
clopidogrel (WRIST PLUS)
Waksman R, et al.
Circulation 2001;103:2332-5
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11352879
Two-year follow-up after beta and gamma
intracoronary radiation therapy for patients with diffuse in-stent restenosis
Waksman R, et al.
Am J Cardiol 2001;88:425-8
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11545769
Geographical miss during catheter-based
intracoronary beta-radiation: incidence and implications in the BRIE study.
Beta-Radiation In Europe
Sianos G, et al.
J Am Coll Cardiol 2001;38:415-20
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11499732
Intracoronary beta-Radiation Exacerbates
Long-Term Neointima Formation in Balloon-Injured Pig Coronary Arteries
Coussement PK, et al.
Circulation 2001;104:2459-64
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11705825
CME Cybersession
New directions in brachytherapy
http://cme.cybersessions.org/dukeu-port19jul00/index.html
July 19, 2000
Drs James Zidar (chair), Ron Waksman, and Raoul Bonan discuss the history of treatments for restenosis and the evolving use of brachytherapy for the treatment of in-stent
restenosis.
Review
Catheter-based Endovascular Radiation Therapy Devices
by Nadir M Ali et al
Vascular Radiotherapy Monitor © 2000
Click here to view the full article
Comparison of the main technical features as well as advantages and disadvantages of intravascular radiotherapy systems used in clinical studies
Review
Catheter-based Coronary Intravascular Brachytherapy Trials
by Prabhakar Tripuraneni
Vascular Radiotherapy Monitor © 2000
Click here to view the full article
Excellent overview of the clinical trials with gamma and beta intravascular radiotherapy
systems. Both have been shown to profoundly reduce recurrence of restenosis in patients with in-stent restenosis
PREVENT Trial - Inhibition of restenosis with beta-emitting
radiotherapy: Report of the Proliferation Reduction with Vascular Energy Trial
Raizner AE et al
Circulation 2000;102:951-8
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010961957
Beta-radiotherapy with a centered (32)P source was highly effective in inhibiting restenosis at the target site after stent or balloon
angioplasty. Edge narrowing and late thrombotic events observed
BETA WRIST Trial - Intracoronary beta-radiation therapy inhibits recurrence of in-stent restenosis
Waksman R et al.
Circulation 2000;101:1895-8
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010779453
In this registry, beta-radiation with a 90-yttrium source used as adjunct therapy for patients with ISR resulted in a lower-than-expected rate of angiographic and clinical
restenosis. Click here to view the comment from TCTMD.com
Dose-Finding Study - Endoluminal Beta-Radiation Therapy for the Prevention of Coronary Restenosis after Balloon Angioplasty
Verin V et al
N Engl J Med 2001;344:243
http://www.nejm.org/content/2001/0344/0004/0243.asp
Intracoronary beta-radiation therapy produces a significant dose-dependent decrease in the rate of restenosis after
angioplasty. An 18-Gy dose not only prevents the renarrowing of the lumen typically observed after successful balloon
angioplasty, but actually induces luminal enlargement
GAMMA-1 Trial - Localized Intracoronary Gamma-Radiation Therapy to Inhibit the Recurrence of Restenosis after Stenting
Leon MB et al
N Engl J Med 2001;344:250
http://www.nejm.org/content/2001/0344/0004/0250.asp
Intracoronary irradiation with iridium-192 resulted in lower rates of clinical and angiographic
restenosis, although it was also associated with a higher rate of late
thrombosis, resulting in an increased risk of myocardial infarction. If the problem of late thrombosis within the stent can be
overcome, intracoronary irradiation with iridium-192 may become a useful approach to the treatment of in-stent restenosis
Editorial
Intracoronary Radiotherapy for Restenosis
Sheppard R and Eisenberg MJ
N Engl J Med 2001;344:295
http://www.nejm.org/content/2001/0344/0004/0295.asp
Intracoronary radiotherapy is a new, exciting technology that is still in its
infancy. The recent FDA approval of two devices for intracoronary radiotherapy should not be interpreted as carte blanche for the indiscriminate application of the
technique. The FDA approval will permit to perform additional trials with larger numbers of
patients, in different populations of patients, and with long-term follow-up. These trials will allow to assess whether the clinical benefits of intracoronary radiotherapy outweigh its
risks. Until this question is answered, physicians should remain cautious in their use of intracoronary radiotherapy for the prevention and treatment of restenosis
Editorial
FDA Approval of Coronary-Artery Brachytherapy
Sapirstein W Zuckerman B and Dillard J
N Engl J Med 2001;344:297
http://www.nejm.org/content/2001/0344/0004/0297.asp
Many questions concerning the safety of ionizing energy for the treatment of vascular lesions remain
unanswered. Irradiation of blood vessels has previously been implicated in the formation of
aneurysms. Mitogenic stimulation by low-level radiation that penetrates beyond the targeted treatment areas raises the specter of delayed oncogenesis in neighboring soft tissue and has been implicated in the constriction of vessels at the margins of irradiated stents -- the so-called "candy wrapper" or "edge"
effect. These issues must be resolved with carefully crafted clinical trials, the results of which could justify the evidence-based expansion of indications for a promising therapy for coronary and other vascular
disease. Nevertheless, at this time, brachytherapy appears to provide a valuable addition to the armamentarium of the interventional
cardiologist.
Late-Breaking Clinical Trial
INHIBIT Trial (Beta Radiation to Inhibit Recurrence of In-Stent
Restenosis).
Clinical and Angiographic Results of the Multicenter,
Randomized, Double-Blind Study
Waksman R Presented at the AHA 2000 Meeting Abstract
Circulation. 2000;102:e9046
The INHIBIT trial assessed the safety and effectiveness of intracoronary beta radiation in 332 patients with in-stent
restenosis. The Guidant-sponsored trial successfully demonstrated a significant reduction in the primary clinical and angiographic endpoints of MACE TLR at 9 months by 56%, MACE with any TVR by 33%, and late thrombosis rate by binary restenosis by 66%. There were also no differences in the edge effect rates between the active and control treated
groups.
Click here or here to view the INHIBIT slide set. For additional Comments Click here
Review
The role of IVUS imaging in vascular brachytherapy
by Carlier SG et al
Int J Cardiovasc Intervent 2000; 3: 3–12
Click here to view the full article
Review of the use of IVUS in the clinical studies of brachytherapy conducted to date
Effect of intracoronary gamma-radiation therapy on in-stent restenosis: An IVUS analysis from the GAMMA-1 Study
Mintz GS et al
Circulation 2000;102:2915-8
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0011113039
Gamma-Radiation therapy can effectively prevent recurrent in-stent restenosis by inhibiting neointimal formation within the
stent. At the stent edge, there were no significant differences between
(192)Ir and placebo patients.
Serial Intravascular Ultrasound Analysis of the Impact of Lesion Length on the Efficacy of Intracoronary gamma-Irradiation for Preventing Recurrent In-Stent Restenosis
Ahmed JM Leon MB
Circulation 2001;103 188-191
http://circ.ahajournals.org/cgi/content/abstract/103/2/188
Brachytherapy may be less effective in longer ISR lesions because of the greater variability and longer source-to-target distances in diffuse
ISR.
Late thrombosis following intracoronary brachytherapy
Waksman R et al.
Catheter Cardiovasc Interv 2000;49:344-7
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010700073
Radiation is also known to delay the healing process and may contribute to a new phenomenon of late
thrombosis. This report present two cases of patients with in-stent restenosis who underwent intervention followed by intracoronary vascular radiation therapy
(utilizing beta and gamma radiation) and presented with acute onset of unstable angina. Angiographic study demonstrated late
thrombosis, which were treated successfully with the Angiojet thrombectomy
device.
AHA 2000 Meeting Coverage
Three-year clinical and angiographic follow-up after intracoronary radiation : results of a randomized clinical trial
Teirstein PS et al.
Circulation 2000;101:360-5
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010653825
The early clinical benefits observed after treatment of coronary restenosis with
(192)Ir appear durable at late follow-up. Angiographic restenosis continues to be significantly reduced in
(192)Ir-treated patients, but a small amount of late loss was observed between the 6-month and 3-year follow-up time
points. No events occurred in the (192)Ir group to suggest major untoward effects of vascular
radiotherapy. At 3-year follow-up, vascular radiotherapy continues to be a promising new treatment for
restenosis.
Methodological and clinical implications of the relocation of the minimal luminal diameter after intracoronary radiation therapy. Dose Finding Study Group
Sabate M et al.
J Am Coll Cardiol 2000;36:1536-41
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0011079655
Click here to view the slide
Relocation of the MLD is commonly demonstrated after BA and
brachytherapy, and it should be taken into account during the analysis of the results of radiation clinical
trials.
Geographic miss: a cause of treatment failure in radio-oncology applied to intracoronary radiation therapy
Sabate M et al.
Circulation 2000;101:2467-71
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010831519
Restenosis rate was significantly higher in the injured edges (10% within
IRS, 40.9% in geographic miss edges, and 1.9% in uninjured edges; P<0.001) supporting the hypothesis that the combination of injury and low-dose beta- radiation induces deleterious
outcome.
Intracoronary beta-radiation therapy inhibits
recurrence of in-stent restenosis
Waksman R, et al.
Circulation 2000;101:1895-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10779453
http://www.circulationaha.org/cgi/content/full/101/16/1895
Intracoronary gamma-radiation therapy after
angioplasty inhibits recurrence in patients with in-stent restenosis
Waksman R, et al.
Circulation 2000;101:2165-71.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10801757
http://www.circulationaha.org/cgi/content/full/101/18/2165
Effect of intracoronary gamma-radiation therapy
on in-stent restenosis: An intravascular ultrasound analysis from the gamma-1
study
Mintz GS, et al.
Circulation 2000;102:2915-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=11113039
http://www.circulationaha.org/cgi/content/full/102/24/2915
Intracoronary brachytherapy not associated with
changes in major side branches
Cottin Y, et al.
Catheter Cardiovasc Interv 2000;51:154-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=11025567
Serial volumetric intravascular ultrasound
analysis of the efficacy of beta irradiation in preventing recurrent in-stent
restenosis
Bhargava B, et al.
Am J Cardiol 2000;85:651-3, A10.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=11078283
Safety of intracoronary gamma-radiation on
uninjured reference segments during the first 6 months after treatment of
in-stent restenosis: a serial intravascular ultrasound study
Ahmed JM, et al.
Circulation 2000;101:2227-30.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10811587
http://www.circulationaha.org/cgi/content/full/101/19/2227
Two-year follow-up after catheter-based
radiotherapy to inhibit coronary restenosis
Teirstein PS, et al.
Circulation 1999;99:243-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9892590
http://www.circulationaha.org/cgi/content/full/99/2/243
Radiation vascular therapy: a novel approach to
preventing restenosis
Williams DO.
Am J Cardiol 1998;81:18E-20E.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9551590
Intracoronary brachytherapy in the Cath Lab.
Physics dosimetry, technology and safety considerations
Waksman R.
Herz 1998;23:401-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9816527
Endovascular brachytherapy: overcoming "practical"
obstacles
Waksman R.
Am J Cardiol 1998;81:21E-26E.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9551591
A subgroup analysis of the Scripps Coronary
Radiation to Inhibit Proliferation Poststenting Trial
Teirstein PS, et al.
Int J Radiat Oncol Biol Phys 1998;42:1097-104.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9869235
Gamma versus beta radiation for the treatment
of restenosis
Teirstein PS.
Herz 1998;23:335-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9816518
Radiotherapy to inhibit coronary restenosis:
kind of a light at the end of the tunnel?
Teirstein PS.
Eur Heart J 1998;19:3-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9503167
Cellular and molecular mechanisms of radiation
inhibition of restenosis. Part I: role of the macrophage and platelet-derived
growth factor
Rubin P, et al.
Int J Radiat Oncol Biol Phys 1998;40:929-41.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9531379
Intracoronary radiation with a 32P source wire
Lee DP, et al.
Herz 1998;23:362-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9816522
Endovascular beta-radiation to reduce
restenosis after coronary balloon angioplasty: results of the beta energy
restenosis trial (BERT)
King SB, 3rd, et al.
Circulation 1998;97:2025-30.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9610532
Catheter-based radiotherapy to inhibit
restenosis after coronary stenting
Teirstein PS, et al.
N Engl J Med 1997;336:1697-703.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9180087
Intravascular radiation therapy in
atherosclerotic disease: promises and premises
Bertrand OF, et al.
Eur Heart J 1997;18:1385-95.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9458443
Long-term angiographic and clinical outcome
after percutaneous transluminal coronary angioplasty and intracoronary radiation
therapy in humans
Circulation 1997;96:1067-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9286927
The dose distribution produced by a 32P source
for endovascular irradiation
Xu Z, et al.
Int J Radiat Oncol Biol Phys 1996;36:933-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8960523
Intracoronary irradiation: dose response for
the prevention of restenosis in swine
Weinberger J, et al.
Int J Radiat Oncol Biol Phys 1996;36:767-75.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8960502
Local catheter-based intracoronary radiation
therapy for restenosis
Waksman R.
Am J Cardiol 1996;78:23-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8751843
192IR endovascular brachytherapy for avoidance
of intimal hyperplasia after percutaneous transluminal angioplasty and stent
implantation in peripheral vessels: 6 years of experience
Schopohl B, et al.
Int J Radiat Oncol Biol Phys 1996;36:835-40.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8960510
Endovascular beta-irradiation after
percutaneous transluminal coronary balloon angioplasty
Popowski Y, et al.
Int J Radiat Oncol Biol Phys 1996;36:841-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8960511
Management of peripheral vascular disease:
innovative approaches using radiation therapy
Nori D, et al.
Int J Radiat Oncol Biol Phys 1996;36:847-56.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8960512
High dose rate intracoronary radiation for
inhibition of neointimal formation in the stented and balloon-injured porcine
models of restenosis: angiographic, morphometric, and histopathologic analyses
Mazur W, et al.
Int J Radiat Oncol Biol Phys 1996;36:777-88.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8960503
Endovascular brachytherapy to inhibit coronary
artery restenosis: an introduction to the SCRIPPS Coronary Radiation to Inhibit
Proliferation Post Stenting trial
Massullo V, et al.
Int J Radiat Oncol Biol Phys 1996;36:973-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8960532
The potential role of external beam radiation
in preventing restenosis after coronary angioplasty
Koh WJ, et al.
Int J Radiat Oncol Biol Phys 1996;36:829-34.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8960509
Pure beta-particle-emitting stents inhibit
neointima formation in rabbits
Hehrlein C, et al.
Circulation 1996;93:641-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8640989
Experimental results with endovascular
irradiation via a radioactive stent
Carter AJ, et al.
Int J Radiat Oncol Biol Phys 1996;36:797-803.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8960505
Dosimetric considerations for catheter-based
beta and gamma emitters in the therapy of neointimal hyperplasia in human
coronary arteries
Amols HI, et al.
Int J Radiat Oncol Biol Phys 1996;36:913-21.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8960521
Dosimetry of a radioactive coronary balloon
dilatation catheter for treatment of neointimal hyperplasia
Amols HI, et al.
Med Phys 1996;23:1783-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8946374
Intracoronary irradiation markedly reduces
neointimal proliferation after balloon angioplasty in swine: persistent benefit
at 6-month follow-up
Wiedermann JG, et al.
J Am Coll Cardiol 1995;25:1451-6.
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