Restenosis Prevention 1977-2001
ESC 2001 Meeting Coverage
AHA 2001 Meeting Coverage
TCTMD Slide Sets
TCT 2001 Expert Presentations
Novel Stent Designs for Site-Specific Drug Delivery
Intravascular sonotherapy decreases
neointimal hyperplasia after stent implantation in swine
Fitzgerald PJ, et al.
Circulation 2001;103:1828-31
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11294798
In this swine peripheral model, intravascular sonotherapy seemed to decelerate
cellular proliferation and decrease in-stent hyperplasia. Therefore,
intravascular sonotherapy may be an effective form of nonionizing energy to
reduce in-stent restenosis.
Treatment of Chlamydia pneumoniae infection
with roxithromycin and effect on neointima proliferation after coronary stent
placement (ISAR-3): a randomised, double-blind, placebo-controlled trial
Neumann F, et al.
Lancet 2001;357:2085-9
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11445102
The cure for in-stent restenosis: not antibiotics: The chlamydia story rolls on.
Large scale trials on the use of antibiotic treatment to reduce coronary event
rates have been inconclusive. This study of 1010 patients looked for a reduction
in in-stent restenosis (31% v 29%, p = 0.43) or death/MI rates at one year (7% v
6%, p = 0.45) with azithromycin versus placebo. None were seen, although a
subanalysis suggested treating those with high chlamydia titres might be of
benefit. More studies are needed.
Effect of ACE inhibitors on angiographic
restenosis after coronary stenting (PARIS): a randomised, double-blind,
placebo-controlled trial
Meurice T, et al.
Lancet 2001;357:1321-4
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11343737
Contrary to our expectations, ACE inhibitor treatment did not reduce restenosis
after coronary stent implantation in patients with DD genotype, but was
associated with an exaggerated restenotic process when compared with
administration of placebo. Late loss in minimum lumen diameter was significantly
higher in the quinapril group than in the controls (mean 1.11 mm [SD 0.70] vs
0.76 mm [0.60]; p=0.018).
Local delivery of enoxaparin to decrease
restenosis after stenting: results of initial multicenter trial: Polish-American
Local Lovenox NIR Assessment study (The POLONIA study)
Kiesz RS, et al.
Circulation 2001;103:26-31
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11136681
This is the first prospective randomized trial in which the local delivery of a
drug, enoxaparin, resulted in significant reduction in late luminal loss and
restenosis after stent implantation in de novo coronary lesion (bynary
restenosis occurred in 10% of patients in the enoxaparin group and in 24% of
patients in the systemic heparinization group, P:<0.05).
A RANDOMIZED TRIAL OF THE
LOW-MOLECULAR-WEIGHT HEPARIN CERTOPARIN TO PREVENT RESTENOSIS FOLLOWING CORONARY
ANGIOPLASTY
Coronary angioplasty has become a successful and widely used treatment for
patients with coronary artery disease since its first clinical application in
1977.
J Invas Cardiol 13(11):723-728, 2001
http://cardiology.medscape.com/46738.rhtml?srcmp=card-010402
Association of plasma homocysteine with the
number of major coronary arteries severely narrowed
Schnyder G, et al.
Am J Cardiol 2001;88:1027-30
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11704002
Folate treatment significantly lowers
restenosis rates
http://www.theheart.org/index.cfm?doc_id=27164
Report from New England Journal of Medicine says that folate treatment
significantly decreased the rate of restenosis and the need for
revascularization after PCI.
JIM 2001 Presentations
TCT 2000 Expert Presentation Slides
Nickel and molybdenum contact allergies in patients with coronary in- stent restenosis
Koster R et al.
Lancet 2000;356:1895-7
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0011130387
Patients with allergic patch-test reactions to nickel and molybdenum had a higher frequency of in-stent restenoses than patients without
hypersensitivity. Allergic reactions to nickel and molybdenum released from stents may be one of the triggering mechanisms for in-stent
restenosis.
In vitro analyses of diamond-like carbon coated stents. Reduction of metal ion release, platelet activation, and thrombogenicity
Gutensohn K et al.
Thromb Res 2000;99:577-85
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010974344
The purpose of this study was to evaluate in vitro the biocompatibility of stents coated with diamond-like carbon
(DLC).Atomic adsorption spectrophotometry analyses revealed a significant release of nickel and chromium metal ions by non-coated stents over a storage period of 96 hours in human plasma (p<0.05). In
contrast, only minimal concentrations of released ions could be detected in the case of DLC-coated
stents. Results: High concentrations of molybdenum and manganese ions were released from non-coated stents (p<0.05), while release of these ions from DLC-coated stents was virtually undetectable (p=0.1 for molybdenum and p=0.4 for manganese). Coating of intracoronary stents with diamond-like carbon significantly improves
biocompatibility. This biocompatible coating may therefore contribute to a reduction in
thrombogenicity.
Optimally deployed stents in the treatment of restenotic versus de novo lesions
Gruberg L et al.
Am J Cardiol 2000;85:333-7
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0011078302
Optimal stent deployment for restenotic and de novo lesions has favorable short- and long-term
outcome. However, the incidence of target lesion revascularization was significantly greater in restenotic lesions (25.1% vs 13.0%, p = 0.001). Saphenous vein graft lesions and diabetes mellitus were confirmed as other independent risk factors for clinical restenosis
CAPARES - Restenosis and clinical outcome in patients treated with amlodipine after angioplasty: results from the Coronary AngioPlasty Amlodipine REStenosis Study
Jorgensen B et al.
J Am Coll Cardiol 2000;35:592-9
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010716459
Amlodipine therapy starting two weeks before PTCA did not reduce luminal
loss, but the incidence of repeat PTCA and the composite major adverse clinical events were significantly reduced during the four-month follow-up period after PTCA with amlodipine as compared with placebo
EUROCARE - Carvedilol for prevention of restenosis after directional coronary atherectomy : final results of the European carvedilol atherectomy restenosis trial
Serruys PW et al.
Circulation 2000;101:1512-8
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010747343
The maximum recommended daily dose of the antioxidant and beta-blocker carvedilol failed to reduce restenosis after successful
atherectomy. These findings are in contrast to those of the Multivitamins and Probucol Trial, which raises doubts regarding the validity of the interpretation that restenosis reduction by probucol was via antioxidant
effects. The relationship between antioxidant agents and restenosis remains to be
elucidated.
Local paclitaxel delivery for the prevention of restenosis: biological effects and efficacy in vivo
Herdeg C et al.
J Am Coll Cardiol 2000;35:1969-76
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010841250
Local delivery of paclitaxel resulted in reduced neointimal stenosis and enlargement in vessel
size. Both these effects contribute to a preservation of vessel shape and are likely to be caused by a structural alteration of the cytoskeleton
Vascular remodeling and the local delivery of cytochalasin B after coronary angioplasty in humans
Lehmann KG et al.
J Am Coll Cardiol 2000;35:583-91
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010716458
Cytochalasin B can be safely administered by local delivery after successful coronary angioplasty and warrants further study of its efficacy in reducing restenosis
HIPS - Heparin infusion prior to stenting trial: final results of a prospective, randomized, controlled trial evaluating the effects of local vascular delivery on intimal hyperplasia
Wilensky RL et al.
Am Heart J 2000;139:1061-70
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010827388
Local delivery of 5000 U heparin into the arterial wall before stent implantation is safe and
feasible. There was not a favorable effect of locally delivered heparin on
clinical, angiographic, or IVUS end points of restenosis.
Effect of statin therapy on restenosis after coronary stent implantation
Walter DH et al.
Am J Cardiol 2000;85:962-8
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010760335
Statin therapy is associated with reduced recurrence rates and improved clinical outcome after coronary stent
implantation.
From TCTMD
Effect of amlodipine on the progression of
atherosclerosis and the occurrence of clinical events. PREVENT Investigators
Pitt B, et al.
Circulation 2000;102:1503-10.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=11004140
http://www.circulationaha.org/cgi/content/full/102/13/1503
Photoactivation of vascular iNOS and elevation
of cGMP in vivo: possible mechanism for photovasorelaxation and inhibition of
restenosis in an atherosclerotic rabbit models
Kipshidze N, et al.
Photochem Photobiol 2000;72:579-82.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=11045733
The PRESTO (Prevention of restenosis with
tranilast and its outcomes) protocol: a double-blind, placebo-controlled trial
Holmes D, et al.
Am Heart J 2000;139:23-31.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10618558
A randomized placebo-controlled trial of
fluvastatin for prevention of restenosis after successful coronary balloon
angioplasty; final results of the fluvastatin angiographic restenosis (FLARE)
trial
Serruys PW, et al.
Eur Heart J 1999;20:58-69.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10075142
Reduction of restenosis by vessel size adapted
percutaneous transluminal coronary angioplasty using intravascular ultrasound
Schroeder S, et al.
Am J Cardiol 1999;83:875-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10190402
Usefulness of subcutaneous low molecular weight
heparin (ardeparin) for reduction of restenosis after percutaneous transluminal
coronary angioplasty
Gimple LW, et al.
Am J Cardiol 1999;83:1524-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10363865
Effects of cilostazol on late lumen loss after
Palmaz-Schatz stent implantation
Yamasaki M, et al.
Cathet Cardiovasc Diagn 1998;44:387-91.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9716201
Effect of warfarin on rate of restenosis after
PTCA
ten Berg JM, et al.
Circulation 1998;97:2097-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9610545
Effects of probucol and cilostazol alone and in
combination on frequency of poststenting restenosis
Sekiya M, et al.
Am J Cardiol 1998;82:144-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9678282
Effect of high dose verapamil on restenosis
after peripheral angioplasty
Schweizer J, et al.
J Am Coll Cardiol 1998;31:1299-305.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9581724
Prevention of restenosis after angioplasty in
small coronary arteries with probucol
Rodes J, et al.
Circulation 1998;97:429-36.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9490236
Plasma activity and insertion/deletion
polymorphism of angiotensin I- converting enzyme: a major risk factor and a
marker of risk for coronary stent restenosis
Ribichini F, et al.
Circulation 1998;97:147-54.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9445166
Usefulness of enhanced insulin secretion during
an oral glucose tolerance test as a predictor of restenosis after direct
percutaneous transluminal coronary angioplasty during acute myocardial
infarction in patients without diabetes mellitus
Osanai H, et al.
Am J Cardiol 1998;81:698-701.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9527077
Preventive effects of an antiallergic drug,
pemirolast potassium, on restenosis after percutaneous transluminal coronary
angioplasty
Ohsawa H, et al.
Am Heart J 1998;136:1081-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9842024
Influence of gradually increased slow balloon
inflation on restenosis after coronary angioplasty
Miketic S, et al.
Am Heart J 1998;135:709-13.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9539490
Lipid-lowering therapy after coronary
revascularization: the interventional cardiologist's perspective
Lansky AJ, et al.
Am J Cardiol 1998;81:55E-62E.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9551596
Human endothelial nitric oxide synthase gene
transfer inhibits vascular smooth muscle cell proliferation and neointima
formation after balloon injury in rats
Janssens S, et al.
Circulation 1998;97:1274-81.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9570198
Comparison of aggressive versus nonaggressive
balloon dilatation for stent deployment on late loss and restenosis in native
coronary arteries
Goldberg SL, et al.
Am J Cardiol 1998;81:708-12.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9527079
Six-month angiographic and clinical follow-up
of patients prospectively randomized to receive either tirofiban or placebo
during angioplasty in the RESTORE trial. Randomized Efficacy Study of Tirofiban
for Outcomes and Restenosis
Gibson CM, et al.
J Am Coll Cardiol 1998;32:28-34.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9669245
Prolonged thrombin inhibition reduces
restenosis after balloon angioplasty in porcine coronary arteries
Gallo R, et al.
Circulation 1998;97:581-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9494029
Medical therapies for the prevention of
restenosis after percutaneous coronary interventions
Frishman WH, et al.
Curr Probl Cardiol 1998;23:534-635.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9805205
Aggressive lipid lowering in postcoronary
angioplasty patients with elevated cholesterol (the Lovastatin Restenosis Trial)
Boccuzzi SJ, et al.
Am J Cardiol 1998;81:632-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9514463
Effectiveness of an antioxidant in preventing
restenosis after percutaneous transluminal coronary angioplasty: the Probucol
Angioplasty Restenosis Trial
Yokoi H, et al.
J Am Coll Cardiol 1997;30:855-62.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9316509
Stent restenosis: can effective antithrombotic
therapy be protective?
Willerson JT.
Circulation 1997;96:383-5.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9244196
Effects of octreotide treatment on restenosis
after coronary angioplasty: results of the VERAS study. VErringerung der
Restenoserate nach Angioplastie durch ein Somatostatin-analogon
von Essen R, et al.
Circulation 1997;96:1482-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9315535
Beta-radiation to reduce restenosis. Too
little, too soon?
Teirstein P.
Circulation 1997;95:1095-7.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9054831
Catheter-based radiotherapy to inhibit
restenosis after coronary stenting
Teirstein PS, et al.
N Engl J Med 1997;336:1697-703.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9180087
Probucol and multivitamins in the prevention of
restenosis after coronary angioplasty. Multivitamins and Probucol Study Group
Tardif JC, et al.
N Engl J Med 1997;337:365-72.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9241125
Reduction of restenosis after angioplasty in an
atheromatous rabbit model by suicide gene therapy
Steg PG, et al.
Circulation 1997;96:408-11.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9244204
Probucol and multivitamins in the prevention of
restenosis after coronary angioplasty
Sirtori CR, et al.
N Engl J Med 1997;337:1918; discussion 1919.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9417525
Local intramural delivery of L-arginine
enhances nitric oxide generation and inhibits lesion formation after balloon
angioplasty
Schwarzacher SP, et al.
Circulation 1997;95:1863-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9107174
A role for intercellular adhesion molecule-1 in
restenosis
Plow EF, et al.
Circulation 1997;95:1355-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9118497
Effect of serotonin, thromboxane A2, and
specific receptor antagonists on vascular smooth muscle cell proliferation
Pakala R, et al.
Circulation 1997;96:2280-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9337201
Inhibition of tissue factor-mediated
coagulation markedly attenuates stenosis after balloon-induced arterial injury
in minipigs
Oltrona L, et al.
Circulation 1997;96:646-52.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9244238
Immunization with homologous oxidized low
density lipoprotein reduces neointimal formation after balloon injury in
hypercholesterolemic rabbits
Nilsson J, et al.
J Am Coll Cardiol 1997;30:1886-91.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9385923
Inhibition of von Willebrand factor binding to
platelet GP Ib by a fractionated aurintricarboxylic acid prevents restenosis
after vascular injury in hamster carotid artery
Matsuno H, et al.
Circulation 1997;96:1299-304.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9286962
PAI-1 inhibits neointimal formation after
arterial injury in mice: a new target for controlling restenosis?
Loskutoff DJ.
Circulation 1997;96:2772-4.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9386134
Local delivery of ethanol inhibits intimal
hyperplasia in pig coronary arteries after balloon injury
Liu MW, et al.
Circulation 1997;96:2295-301.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9337203
Probucol and multivitamins in the prevention of
restenosis after coronary angioplasty
Lisi DM.
N Engl J Med 1997;337:1919.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9417527
Sustained local delivery of dexamethasone by a
novel intravascular eluting stent to prevent restenosis in the porcine coronary
injury model
Lincoff AM, et al.
J Am Coll Cardiol 1997;29:808-16.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9091528
Pathophysiology and pharmacological approaches
for prevention of coronary artery restenosis following coronary artery balloon
angioplasty and related procedures
Landzberg BR, et al.
Prog Cardiovasc Dis 1997;39:361-98.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9050821
Effect of the direct nitric oxide donors
linsidomine and molsidomine on angiographic restenosis after coronary balloon
angioplasty. The ACCORD Study. Angioplastic Coronaire Corvasal Diltiazem
Lablanche JM, et al.
Circulation 1997;95:83-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8994421
Effect of nadroparin, a low-molecular-weight
heparin, on clinical and angiographic restenosis after coronary balloon
angioplasty: the FACT study. Fraxiparine Angioplastie Coronaire Transluminale
Lablanche JM, et al.
Circulation 1997;96:3396-402.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9396433
Predictive factors of restenosis after coronary
stent placement
Kastrati A, et al.
J Am Coll Cardiol 1997;30:1428-36.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9362398
Probucol and multivitamins in the prevention of
restenosis after coronary angioplasty
Jay SJ.
N Engl J Med 1997;337:1918-9; discussion 1919.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9417526
Association of an acute reduction in
lipoprotein(a) with coronary artery restenosis after percutaneous transluminal
coronary angioplasty
Horie H, et al.
Circulation 1997;96:166-73.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9236431
Preventing coronary restenosis and
complications
Holmes DR, Jr.
N Engl J Med 1997;336:1748-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9180094
Effects of coronary stenting on restenosis and
occlusion after angioplasty of the culprit vessel in patients with recent
myocardial infarction
Bauters C, et al.
Circulation 1997;96:2854-8.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9386149
Intimal hyperplasia after balloon injury is
attenuated by blocking selectins
Barron MK, et al.
Circulation 1997;96:3587-92.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9396459
Paclitaxel inhibits arterial smooth muscle cell
proliferation and migration in vitro and in vivo using local drug delivery
Axel DI, et al.
Circulation 1997;96:636-45.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9244237
Preventive effects of probucol on restenosis
after percutaneous transluminal coronary angioplasty
Watanabe K, et al.
Am Heart J 1996;132:23-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8701872
Possible prevention of postangioplasty
restenosis by ascorbic acid
Tomoda H, et al.
Am J Cardiol 1996;78:1284-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8960592
Lovastatin plus probucol for prevention of
restenosis after percutaneous transluminal coronary angioplasty
O'Keefe JH, Jr., et al.
Am J Cardiol 1996;77:649-52.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8610621
Intracoronary irradiation markedly reduces
neointimal proliferation after balloon angioplasty in swine: persistent benefit
at 6-month follow-up
Wiedermann JG, et al.
J Am Coll Cardiol 1995;25:1451-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7722148
Intracoronary radiation before stent
implantation inhibits neointima formation in stented porcine coronary arteries
Waksman R, et al.
Circulation 1995;92:1383-6.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7664415
Endovascular low-dose irradiation inhibits
neointima formation after coronary artery balloon injury in swine. A possible
role for radiation therapy in restenosis prevention
Waksman R, et al.
Circulation 1995;91:1533-9.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7867195
Prevention of cardiovascular ischemic
complications with new platelet glycoprotein IIb/IIIa inhibitors
Topol EJ.
Am Heart J 1995;130:666-72.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7668215
Enhancing safety and outcomes with the newer
antithrombotic and antiplatelet agents
Tcheng JE.
Am Heart J 1995;130:673-9.
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