Alcohol septal ablation 2000-2001

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TCT 2001 Featured Presentations

TCTMD - Fellows Course Slide Sets

Regression of left ventricular hypertrophy after nonsurgical septal reduction therapy for hypertrophic obstructive cardiomyopathy
Mazur W, et al.
Circulation 2001;103:1492-6
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11257074 

Clinical Cardiology: New Frontiers
New Concepts in Hypertrophic Cardiomyopathies, Part I
Robert Roberts and Ulrich Sigwart
Circulation 2001;104 2113-2116
http://circ.ahajournals.org/cgi/content/full/104/17/2113

Clinical Cardiology: New Frontiers
New Concepts in Hypertrophic Cardiomyopathies, Part II
Robert Roberts and Ulrich Sigwart
Circulation 2001;104 2249-2252
http://circ.ahajournals.org/cgi/content/full/104/18/2249

Anatomy of the first septal perforating artery: a study with implications for ablation therapy for hypertrophic cardiomyopathy
Singh M, et al.
Mayo Clin Proc 2001;76:799-802
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11499819 

Microvascular obstruction after nonsurgical septal reduction for the treatment of hypertrophic cardiomyopathy
Wu KC, et al.
Circulation 2001;104:1868
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11591628 

Efficacy of nonsurgical septal reduction therapy in symptomatic patients with obstructive hypertrophic cardiomyopathy and provocable gradients
Lakkis N, et al.
Am J Cardiol 2001;88:583-6
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11524078

Pressure-guided nonsurgical myocardial reduction induced by small septal infarctions in hypertrophic obstructive cardiomyopathy
Boekstegers P, et al.
J Am Coll Cardiol 2001;38:846-53
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11527644
Pressure-guided NSMR inducing small septal infarctions was sufficient to result in a sustained decrease in LVOT obstruction and to improve symptoms. The incidence of complications, such as complete heart block with necessary permanent pacemaker implantation (<10%), seems to be diminished by minimizing the infarct size.

Progressive decrease of outflow gradient and septum thickness after percutaneous alcoholization of the interventricular septum in hypertrophic obstructive cardiomyopathy
 
Airoldi F et al.
  Ital Heart J 2000;1:200-6
  http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010806987 
  Click here to view the full article
PTSMA of the intraventricular septum effectively relieves symptoms in selected patients with hypertrophic obstructive cardiomyopathy. The immediate decrease in intraventricular gradient is followed by a further decline at follow-up with a progressive reduction in the intraventricular septum thickness.

Alcohol septal ablation in hypertrophic obstructive cardiomyopathy: The need for a registry
  W. Spencer R. Roberts
  Circulation 2000; 102: 600-1 
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Nonsurgical septal reduction therapy for hypertrophic obstructive cardiomyopathy: one-year follow-up
  Lakkis NM Nagueh SF Dunn JK, Killip D Spencer WH 3rd 
  J Am Coll Cardiol 2000; 36: 852-5
  http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010987610 
Nonsurgical septal reduction therapy is a safe, rational and effective therapy for symptomatic patients with hypertrophic obstructive cardiomyopathy. Favorable outcomes were found up to one year after the procedure on first 50 hypertrophic obstructive cardiomyopathy patients to undergo nonsurgical septal reduction therapy in the United States.

Click here to view the full article synopsis.

Percutaneous transluminal septal myocardial ablation for hypertrophic obstructive cardiomyopathy: long term follow up of the first series of 25 patients 
 
Faber L et al. 
  Heart 2000;83:326-31 
  http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010677415 
PTSMA is an effective non-surgical technique for reduction of symptoms and LVOTG in HOCM. Prospective, long term observations of larger populations are necessary in order to determine the definitive significance of the procedure.

Role of alcohol septal ablation in treatment of obstructive hypertrophic cardiomyopathy 
  Maron BJ 
  Lancet 2000;355:425-6 
 
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010841119 

Percutaneous transluminal septal myocardial ablation: a new treatment for hypertrophic obstructive cardiomyopathy
  Seggewiss H 
  Eur Heart J 2000;21:704-7 
  http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0010739723